European Respiratory Journal 2022 60(suppl 66): 2671;
Page Source : https://doi.org/10.1183/13993003.congress-2022.2671
L C Sia, C K Wong, N Z M Ooi, W Y Chan, Y Pang, C K Liam, C I Soo, J L Tan, M E Poh, K K Chin, T C Loh, N H Ibrahim, V Munusamy.
University Malaya Medical Centre, Kuala Lumpur, Malaysia
Ministry of Health, Kuala Lumpur, Malaysia
Background: The evidence for management of severe COVID-19 with persistent respiratory failure (PRF) after acute treatment is scarce, despite some authors reported a good response to corticosteroid in histological proven secondary organising pneumonia (OP).
Objectives: This study aimed to study the disease course of COVID-19 patients with persistent respiratory failure, and its radiological pattern.
Methods: A single centre retrospective cohort study on severe COVID-19 patients was conducted from January 2021 to June 2021. All radiological imaging and data were retrieved from electronic database.
Results: Severe COVID-19 pneumonia had a 78% (584/750) survival in our cohort. Among the survival, 48% (279/584) had PRF beyond 14 days of illness and 10% of them required oxygen therapy upon discharge. Eighty-six percent (240/279) of patients with PRF had a HRCT performed. Eighty percent (187/240) of them attended clinic follow up with 81% had a radiological pattern consistent with OP. The mean severity CT score was 10 (SD±3). [Jin C et al. Front Public Heal.2020;8] Seventy-eight percent of patients were perceived with WHO functional class of 1-2. Sixty-eight percent of patients (128/187) were given short course of prednisolone during admission with tapering doses. The mean prednisolone dose was 0.69mg/kg/day with a mean duration of 47 days (SD±18). Seventy-eight percent (146/187) had a follow up chest x-ray (CXR) at 12±8 weeks. Only 6.4% (12/187) of them had abnormal CXR findings whereby two patients were later confirmed to have pulmonary tuberculosis.
Conclusion: Radiological pattern of OP is common in COVID-19 with PRF. HRCT is a non-invasive tool to assess this entity.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 2671.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
